herbaГербариумHerbarium3034-3925ООО «ЦФА»10.33380/3034-3925-2026-3-4-96herba-96Research ArticleБИОЛОГИЧЕСКАЯ АКТИВНОСТЬ ПРИРОДНЫХ СУБСТАНЦИЙBIOLOGICAL ACTIVITY OF NATURAL SUBSTANCESНейротропная активность группы стероидных сапонинов корней и корневищ диоскореи ниппонской (Dioscorea nipponica Makino) (обзор)Neurotropic activity of the steroid saponin group from roots and rhizomes of Dioscorea nipponica Makino (review)https://orcid.org/0009-0005-1639-095XГорелкинаВ. Д.GorelkinaVictoria D.

197022, г. Санкт-Петербург, вн. тер. г. муниципальный округ Аптекарский остров, ул. Профессора Попова, д. 14, лит. А

14A, Professora Popova str., Aptekarsky Ostrov Municipal Okrug, Saint Petersburg, 197022

viktoriya.gorelkina@spcpu.ruhttps://orcid.org/0009-0008-4730-7188МироненкоМ. В.MironenkoMaria V.

197022, г. Санкт-Петербург, вн. тер. г. муниципальный округ Аптекарский остров, ул. Профессора Попова, д. 14, лит. А

14A, Professora Popova str., Aptekarsky Ostrov Municipal Okrug, Saint Petersburg, 197022

mariya.mironenko@spcpu.ruhttps://orcid.org/0000-0001-7559-186XБолотоваВ. Ц.BolotovaVera Ts.

197022, г. Санкт-Петербург, вн. тер. г. муниципальный округ Аптекарский остров, ул. Профессора Попова, д. 14, лит. А

14A, Professora Popova str., Aptekarsky Ostrov Municipal Okrug, Saint Petersburg, 197022

vera.bolotova@pharminnotech.comФедеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный химико-фармацевтический университет» Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России)РоссияSaint Petersburg State Chemical and Pharmaceutical University (SPCPU)Russian Federation20251610202600Принято в печать96Copyright © Горелкина В.Д., Мироненко М.В., Болотова В.Ц., 20252025Горелкина В.Д., Мироненко М.В., Болотова В.Ц.Gorelkina V.D., Mironenko M.V., Bolotova V.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.herbariumjournal.ru/jour/article/view/96Введение

Введение. Цель — обобщение информации о механизмах нейротропной активности группы стероидных сапонинов корней и корневищ диоскореи ниппонской.

Текст

Текст. Нейротропные эффекты стероидных сапонинов диоскореи ниппонской (диосгенина, диосцина, протодиосцина, метилпротодиосцина) включают как неспецифическую нейропротекцию путем снижения нейровоспаления, окислительного стресса и апоптоза, повышения аутофагии и нейрогенеза, так и специфические механизмы, выявленные на моделях отдельных заболеваний, в том числе болезни Альцгеймера, болезни Паркинсона, рассеянного склероза и ишемического инсульта. Также отмечено ноотропное и антидепрессивное действие на некоторых моделях психических расстройств.

Заключение

Заключение. В настоящем обзоре представлены биохимические и молекулярные механизмы, лежащие в основе развития нейротропных эффектов стероидных сапонинов диоскореи ниппонской, широта которых позволяет рассматривать стероидные сапонины как потенциальные объекты для разработки лекарственных препаратов.

Introduction

Introduction. The aim was to summarize information on the mechanisms of neurotropic activity of the steroid saponin group from roots and rhizomes of Dioscorea nipponica Makino.

Text

Text. The neurotropic effects of steroid saponins of Dioscorea nipponica (diosgenin, dioscin, protodioscin, methylprotodioscin) include both nonspecific neuroprotection (reduction of neuroinflammation, oxidative stress, and apoptosis; enhancement of autophagy and neurogenesis) and specific mechanisms identified in models of certain diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and ischemic stroke. Nootropic and antidepressant effects have been noted in models of mental disorders.

Conclusion

Conclusion. This review presents the biochemical and molecular mechanisms underlying the neurotropic effects of steroid saponins of Dioscorea nipponica. The breadth of these effects allows steroid saponins to be considered as potential candidates for drug development.

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The authors declare that there are no conflicts of interest present.